Journal article
NADPH oxidase-mediated redox signaling: Roles in cellular stress response, stress tolerance, and tissue repair
F Jiang, Y Zhang, GJ Dusting
Pharmacological Reviews | Published : 2011
Abstract
NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species (ROS). Accumulating evidence suggests that Nox has an important role in signal transduction in cellular stress responses. We have reviewed the current evidence showing that the Nox system can be activated by a collection of chemical, physical, and biological cellular stresses. In many circumstances, Nox activation fits to the cellular stress response paradigm, in that (1) the response can be initiated by various forms of cellular stresses; (2) Nox-derived ROS may activate mitogen-activated protein kinases (extracellular signalregulated kinase, p38) and c-Jun NH2-terminal kinase, which are the core of the cell ..
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Grants
Awarded by National 973 Basic Research Program of China
Awarded by National High-Tech Research and Development Program of China
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by National Heart Foundation of Australia
Funding Acknowledgements
This work was partially supported by the National 973 Basic Research Program of China [Grants 2010CB732605, 2009CB521900] (to F.J. and Y.Z., respectively); the National High-Tech Research and Development Program of China [Grant 2006AA02A406] (to Y.Z.), the National Health and Medical Research Council (NHMRC) of Australia [Grant 566911] (to G.J.D.); the National Heart Foundation of Australia [Grant-in-Aid G06M2662] (to G.J.D.); a Shandong University Qilu Scholar Professorship (to F.J.); and a NHMRC of Australia Principal Research Fellowship (to G.J.D.).